The Transcription Factors TFEB and TFE3 Link the FLCN-AMPK Signaling Axis to Innate Immune Response and Pathogen Resistance.

El-Houjeiri L, Possik E, Vijayaraghavan T, Paquette M, Martina JA, Kazan JM, Ma EH, Jones R, Blanchette P, Puertollano R, Pause A.

Cell Rep. 2019 Mar 26;26(13):3613-3628.e6. doi: 10.1016/j.celrep.2019.02.102.

PMID: 30917316

 

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Structure and functions of His domain protein tyrosine phosphatase in receptor trafficking and cancer 1.

Desrochers G, Kazan JM, Pause A.

Biochem Cell Biol. 2019 Feb;97(1):68-72. doi: 10.1139/bcb-2017-0322. Epub 2018 Jun 7. Review.

PMID: 29879361

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eIF4A inhibition prevents the onset of cytokine-induced muscle wasting by blocking the STAT3 and iNOS pathways.

Cramer Z, Sadek J, Vazquez GG, Di Marco S, Pause A, Pelletier J, Gallouzi IE.

Sci Rep. 2018 May 30;8(1):8414. doi: 10.1038/s41598-018-26625-9.

PMID: 29849089

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The AMPK agonist 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR), but not metformin, prevents inflammation-associated cachectic muscle wasting.

Hall DT, Griss T, Ma JF, Sanchez BJ, Sadek J, Tremblay AMK, Mubaid S, Omer A, Ford RJ, Bedard N, Pause A, Wing SS, Di Marco S, Steinberg GR, Jones RG, Gallouzi IE.

EMBO Mol Med. 2018 Jul;10(7). pii: e8307. doi: 10.15252/emmm.201708307.

PMID: 29844217

 

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Phosphatidylinositol-5-Phosphate 4-Kinases Regulate Cellular Lipid Metabolism By Facilitating Autophagy.

Lundquist MR, Goncalves MD, Loughran RM, Possik E, Vijayaraghavan T, Yang A, Pauli C, Ravi A, Verma A, Yang Z, Johnson JL, Wong JCY, Ma Y, Hwang KS, Weinkove D, Divecha N, Asara JM, Elemento O, Rubin MA, Kimmelman AC, Pause A, Cantley LC, Emerling BM.

Mol Cell. 2018 May 3;70(3):531-544.e9. doi: 10.1016/j.molcel.2018.03.037.

PMID: 29727621

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Stress granules counteract senescence by sequestration of PAI-1.

Omer A, Patel D, Lian XJ, Sadek J, Di Marco S, Pause A, Gorospe M, Gallouzi IE.

EMBO Rep. 2018 May;19(5). pii: e44722. doi: 10.15252/embr.201744722. Epub 2018 Mar 28.

PMID: 29592859

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Biochemical Measurement of Glycogen: Method to Investigate the AMPK-Glycogen Relationship.

Possik E, Pause A.

Methods Mol Biol. 2018;1732:57-67. doi: 10.1007/978-1-4939-7598-3_4.

PMID: 29480468

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mTOR Pathways in Cancer and Autophagy.

Paquette M, El-Houjeiri L, Pause A.

Cancers (Basel). 2018 Jan 12;10(1). pii: E18. doi: 10.3390/cancers10010018. Review.

PMID: 29329237

 

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AMPK Maintains Cellular Metabolic Homeostasis through Regulation of Mitochondrial Reactive Oxygen Species.

Rabinovitch RC, Samborska B, Faubert B, Ma EH, Gravel SP, Andrzejewski S, Raissi TC, Pause A, St-Pierre J, Jones RG.

Cell Rep. 2017 Oct 3;21(1):1-9. doi: 10.1016/j.celrep.2017.09.026.

PMID: 28978464

 

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Role of ESCRT component HD-PTP/PTPN23 in cancer.

Gingras MC, Kazan JM, Pause A.

Biochem Soc Trans. 2017 Jun 15;45(3):845-854. doi: 10.1042/BST20160332. Review.

PMID: 28620046

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Glycogen: A must have storage to survive stressful emergencies.

Possik E, Pause A.

Worm. 2016 Mar 4;5(2):e1156831. doi: 10.1080/21624054.2016.1156831. eCollection 2016 Apr-Jun.

PMID:27383221

 

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Haploinsufficiency of the ESCRT Component HD-PTP Predisposes to Cancer.

Manteghi S, Gingras MC, Kharitidi D, Galarneau L, Marques M, Yan M, Cencic R, Robert F, Paquet M, Witcher M, Pelletier J, Pause A.

Cell Rep. 2016 May 31;15(9):1893-900. doi: 10.1016/j.celrep.2016.04.076. Epub 2016 May 19.

PMID: 27210750

 

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Chronic AMPK activation via loss of FLCN induces functional beige adipose tissue through PGC-1α/ERRα.

Yan M, Audet-Walsh É, Manteghi S, Dufour CR, Walker B, Baba M, St-Pierre J, Giguère V, Pause A.

Genes Dev. 2016 May 1;30(9):1034-46. doi: 10.1101/gad.281410.116.

PMID: 27151976

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Mitochondrial Phosphoenolpyruvate Carboxykinase Regulates Metabolic Adaptation and Enables Glucose-Independent Tumor Growth.

Vincent EE, Sergushichev A, Griss T, Gingras MC, Samborska B, Ntimbane T, Coelho PP, Blagih J, Raissi TC, Choinière L, Bridon G, Loginicheva E, Flynn BR, Thomas EC, Tavaré JM, Avizonis D, Pause A, Elder DJ, Artyomov MN, Jones RG.

Mol Cell. 2015 Oct 15;60(2):195-207. doi: 10.1016/j.molcel.2015.08.013.

PMID: 26474064

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Interplay of Endosomal pH and Ligand Occupancy in Integrin α5β1 Ubiquitination, Endocytic Sorting, and Cell Migration.

Kharitidi D, Apaja PM, Manteghi S, Suzuki K, Malitskaya E, Roldan A, Gingras MC, Takagi J, Lukacs GL, Pause A.

Cell Rep. 2015 Oct 20;13(3):599-609. doi: 10.1016/j.celrep.2015.09.024. Epub 2015 Oct 8.

PMID: 26456826

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FLCN and AMPK Confer Resistance to Hyperosmotic Stress via Remodeling of Glycogen Stores.

Possik E, Ajisebutu A, Manteghi S, Gingras MC, Vijayaraghavan T, Flamand M, Coull B, Schmeisser K, Duchaine T, van Steensel M, Hall DH, Pause A.

PLoS Genet. 2015 Oct 6;11(10):e1005520. doi: 10.1371/journal.pgen.1005520. eCollection 2015 Oct.

PMID: 26439621

 

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Measuring oxidative stress resistance of Caenorhabditis elegans in 96-well microtiter plates.

Possik E, Pause A.

J Vis Exp. 2015 May 9;(99):e52746. doi: 10.3791/52746.

PMID: 25993260

 

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The ever-evolving role of mTOR in translation.

Fonseca BD, Smith EM, Yelle N, Alain T, Bushell M, Pause A.

Semin Cell Dev Biol. 2014 Dec;36:102-12. doi: 10.1016/j.semcdb.2014.09.014. Epub 2014 Sep 27. Review.

PMID: 25263010

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Folliculin regulates ampk-dependent autophagy and metabolic stress survival.

Possik E, Jalali Z, Nouët Y, Yan M, Gingras MC, Schmeisser K, Panaite L, Dupuy F, Kharitidi D, Chotard L, Jones RG, Hall DH, Pause A.

PLoS Genet. 2014 Apr 24;10(4):e1004273. doi: 10.1371/journal.pgen.1004273. eCollection 2014 Apr.

PMID: 24763318

 

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